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Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Gardiner, Elizabeth; Trevillyan, Janine M; Andrews, Robert; Maisa, Anna; Hearps, Anna C; Al-Tamimi, Mohammad; Crowe, Suzanne M; Hoy, Jennifer F


HIV-positive patients are at increased risk for coronary artery disease (CAD); changes in platelet activation may play a role. This study was performed to determine if levels of soluble glycoprotein VI (sGPVI), a platelet-specific marker of activation, were different in HIV-positive patients compared with HIV-negative controls and further if levels were predictive of CAD in HIV. Twenty-four HIV-positive individuals (HIV cases) with CAD were compared with 46 age- and sex-matched HIV-positive...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Platelets
DOI: 10.1080/09537104.2016.1237627


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