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Reconstruction of a 450-My-old ancestral vertebrate protokaryotype

Kohn, Matthias; Hogel, Joseph; Vogel, W; Minich, Peter; Kehrer-Sawatzki, Hildegard; Graves, Jennifer; Hameister, Horst


From recent work the putative eutherian karyotype from 100 Mya has been derived. Here, we have applied a new in silico technique, electronic chromosome painting (E-painting), on a large data set of genes whose positions are known in human, chicken, zebrafish and pufferfish. E-painting identifies conserved syntenies in the data set, and it enables a stepwise reconstruction of the ancestral vertebrate protokaryotype comprising 11 protochromosomes. During karyotype evolution in land vertebrates...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Trends in Genetics
DOI: 10.1016/j.tig.2006.02.008


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