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Transport of glutathione transferase-fold structured proteins into living cells

Morris, Melanie; Craig, Scott; Sutherland, Teresa; Board, Philip; Casarotto, Marco


Glutathione transferases are a family of enzymes that are traditionally known to contribute to the phase II class of detoxification reactions. However, a novel property of the Schistosoma japonicum glutathione transferase (Sj.GST26) involves its translocation from the external medium into a variety of different cell types. Here we explore the efficiency and mechanism of cell entry for this class of protein. Using flow cytometry and confocal microscopy, we have examined the internalisation of...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biochimica et Biophysica Acta: Biomembranes
DOI: 10.1016/j.bbamem.2008.10.018


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