Friberg, Markus; Gonnet, Pedro; Barral, Yves; Schraudolph, Nicol; Gonnet, Gaston H
Protein translation is a rapid and accurate process, which has been optimized by evolution. Recently, it has been shown that tRNA reusage influences translation speed. We present the tRNA Pairing Index (TPI), a novel index to measure the degree of tRNA reusage in any gene. We describe two variants of the index, how to combine various such indices to a single one and an efficient algorithm for their computation. A statistical analysis of gene expression groups indicate that cell cycle genes have...[Show more]
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