Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
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Poulter, N. S.; Pollitt, Alice Y.; Owen, D. M.; Gardiner, Elizabeth; Andrews, Robert K; Shimizu, H.; Ishikawa, D; Bihan, Dominique; Farndale, R. W.; Moroi, Masaaki; Watson, Steve P; Jung, Stephanie M.
Description
Background: Platelet glycoprotein VI (GPVI) binding to subendothelial collagen exposed upon blood vessel injury initiates thrombus formation. Dimeric GPVI has high affinity for collagen, and occurs constitutively on resting platelets. Objective: To identify higher-order oligomerization (clustering) of pre-existing GPVI dimers upon interaction with collagen as a mechanism to initiate GPVI-mediated signaling. Methods: GPVI was located by use of fluorophore-conjugated GPVI dimer-specific Fab...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/233756 |
Source: | Journal of Thrombosis and Haemostasis |
DOI: | 10.1111/jth.13613 |
Access Rights: | Open Access |
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01_Poulter_Clustering_of_glycoprotein_VI_2017.pdf | 2.19 MB | Adobe PDF |
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