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Increases in Urinary 9a,11b-Prostaglandin F2 Indicate Mast Cell Activation in Wine-Induced Asthma

Misso, Neil L A; Aggarwal, Shashi; Thompson, Philip J; Vally, Hassan


Background: Wine-induced asthmatic symptoms may be caused by sulphite additives. Prostaglandin (PG)D2 and cysteinyl leukotrienes (cysLT) are important mediators of asthmatic responses. To determine whether the sulphite additives in wine alter the production of PGD2 and cysLT, asthmatic patients with compelling histories of wine sensitivity were challenged with high- and low-sulphite wines; the urinary metabolites of PGD2 and cysLT were measured before and after challenge. Methods: Eight...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: International Archives of Allergy and Immunology
DOI: 10.1159/000189195


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