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Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites

Rajendran, Esther; Hapuarachchi, Sanduni; Miller, Catherine M; Fairweather, Stephen; Cai, Yeping; Smith, Nicholas C; Cockburn, Ian; Broer, Stefan; Kirk, Kiaran; van Dooren, Giel

Description

Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Here we demonstrate that members of an apicomplexan-specific protein family—the Novel Putative Transporters (NPTs)—play key roles in the uptake of cationic amino acids. We show that an NPT from Toxoplasma gondii (TgNPT1) is a selective arginine...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/233419
Source: Nature Communications
DOI: 10.1038/ncomms14455
Access Rights: Open Access

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