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Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Hung, Sandy S.-C.; Lesmana, Analie; Peck, Abigail; Lee, Rachel; Tchoubrieva, Elly; Hannan, Katherine; Lin, Jane; Sheppard, Karen E.; Jastrzebski, Katarzyna; Quinn, Leonie; Rothblum, Lawrence I.; Pearson, Richard B; Hannan, Ross; Sanij, Elaine


Transcription of the ribosomal RNA genes (rDNA) by RNA polymerase I (Pol I) is a major control step for ribosome synthesis and is tightly linked to cellular growth. However, the question of whether this process is modulated primarily at the level of transcription initiation or elongation is controversial. Studies in markedly different cell types have identified either initiation or elongation as the major control point. In this study, we have re-examined this question in NIH3T3 fibroblasts...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Gene
DOI: 10.1016/j.gene.2016.12.015


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