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Na+-H+ Exchanger Regulatory Factor 1 is a PDZ Scaffold for the Astroglial Glutamate Transporter GLAST

Lee, Aven; Rayfield, Andrew; Hryciw, Deanne H.; Ma, Theingi Aung; Wang, Dongsheng; Pow, David; Broer, Stefan; Yun, Chris; Poronnik, Philip

Description

Glutamate is a key neurotransmitter and its levels in the synaptic cleft are tightly regulated by reuptake mechanisms that primarily involve transporters in astrocytes. This requires that the glutamate transporters be spatially constrained to effect maximum glutamate transport. GLAST (EAAT1) is the predominant astroglial transporter and contains a class I PDZ-binding consensus (ETKM) in its C-terminus. The epithelial Na+/H+ exchanger regulatory factors NHERF1 and NHERF2 are PDZ proteins that...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/23322
Source: Glia
DOI: 10.1002/glia.20439

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