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Longitudinal changes in subcortical morphology in Huntington Disease and the relationship with clinical, motor and neurocognitive outcomes

Wilkes, Fiona


Huntington disease (HD) is a devastating inherited neurodegenerative disease which causes progressive motor, psychiatric and cognitive disturbances as well as neurodegeneration. Mapping the spatiotemporal progression of neuroanatomical change in HD is fundamental to developing biomeasures suitable for prognostication and to aid in development and testing of potential treatments. The neostriatum is central to HD and is known to start to degenerate more than a decade before observable motor...[Show more]

CollectionsOpen Access Theses
Date published: 2021
Type: Thesis (PhD)
DOI: 10.25911/TKNB-GG08


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Appendix_ Wilkes 2019 IMAGE-HD striatal morphology.pdfSupporting Material1.51 MBAdobe PDFThumbnail
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FWilkes PhD unrestricted sections 2021.pdfThesis Material3.03 MBAdobe PDFThumbnail
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FWilkes PhD restricted chapter 4-6 2021.pdf1.8 MBAdobe PDFThumbnail
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