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Metabolic Alterations During the Growth of Tumour Spheroids

Callaghan, Richard; Bloch, Katarzyna; Smith, Hannah; van Hamel Parsons, Victoria; Gavaghan, David; Kelly, Catherine; Fletcher, Alexander; Maini, Philip


Solid tumours undergo considerable alterations in their metabolism of nutrients in order to generate sufficient energy and biomass for sustained growth and proliferation. During growth, the tumour microenvironment exerts a number of influences (e.g. hypoxia and acidity) that affect cellular biology and the flux or utilisation of fuels including glucose. The tumour spheroid model was used to characterise the utilisation of glucose and describe alterations to the activity and expression of key...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Cell Biochemistry and Biophysics
DOI: 10.1007/s12013-013-9757-7


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