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Antiangiogenic platinum through glycan targeting

Peterson, Erica; Daniel, Gerard A; Katner, Samantha; Bohlmann, Lisa; Chang, Chih-Wei; BEZOS, ANNA; Parish, Christopher; von Itzstein, Mark; Berners-Price, Susan J; Farrell, Nicholas P


Heparan sulfate is identified as a ligand receptor for polynuclear platinum anti-cancer agents through sulfate cluster binding. We present a new biological role for platinum and coordination compounds and a new target for metal-based drugs while presenting a new chemotype for heparanase and growth factor inhibition through modulation (metalloshielding) of their interactions. Masking of extracellular (ECM)-resident heparan sulfate (HS) through metalloshielding results in very effective...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Chemical Science
DOI: 10.1039/c6sc02515c
Access Rights: Open Access


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