Arachidonic Acid Metabolism in Glucocorticoid-Induced Hypertension
1. Products of metabolism of arachidonic acid, such as 20- hydroxyeicosatetraenoic acid (20-HETE), thromboxane A2 (TXA 2) and prostaglandin I2 (PGI2), regulate vascular tone. Among them, 20-HETE is a potent constrictor in small arteries that also has natriuretic properties. The present study investigated changes in urinary concentrations of 20-HETE and metabolites of TXA2 and PGI2 in glucocorticoid-hypertension in rats, a sodium-independent model. 2. Male Sprague-Dawley rats were treated with...[Show more]
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