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Arachidonic Acid Metabolism in Glucocorticoid-Induced Hypertension

Zhang, Yi; Hu, Lexian; Mori, Trevor A; Barden, Anne; Croft, Kevin D; Whitworth, Judith


1. Products of metabolism of arachidonic acid, such as 20- hydroxyeicosatetraenoic acid (20-HETE), thromboxane A2 (TXA 2) and prostaglandin I2 (PGI2), regulate vascular tone. Among them, 20-HETE is a potent constrictor in small arteries that also has natriuretic properties. The present study investigated changes in urinary concentrations of 20-HETE and metabolites of TXA2 and PGI2 in glucocorticoid-hypertension in rats, a sodium-independent model. 2. Male Sprague-Dawley rats were treated with...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.1440-1681.2007.04839.x


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