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Accelerating metabolism and transmembrane cation flux by distorting red blood cells

Kuchel, Philip William; Shishmarev, Dmitry


Under static conditions, mammalian red blood cells (RBCs) require a continuous supply of energy, typically via glucose, to maintain their biconcave disc shape. Mechanical distortion, in a complementary way, should lead to increased energy demand that is manifest in accelerated glycolysis. The experimental challenge in observing this phenomenon was met by reversibly and reproducibly distorting the cells and noninvasively measuring glycolytic flux. This was done with a gel-distorting device that...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Science Advances
DOI: 10.1126/sciadv.aao1016
Access Rights: Open Access


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