Abstract IA10: Drugging the ribosome at the level of synthesis and translation to treat solid and hematologic cancers
Hannan, Ross; Hein, Nadine; Hannan, Kate; Poortinga, Gretchen; Sanji, Elaine; Sornkom, Jirawas; MacLachlan, Kylee; Cuddihy, Andrew; Cullinane, C; Furic, Luc; Drygin, Denis; Haddach, Mustapha; Harrison, Simon; McArthur, Grant; Pearson, Richard B
Recent findings by our group have been instrumental in the development of the novel selective inhibitors of RNA Polymerase I (Pol I) (Drygin et al., Cancer Research, 2011; Bywater et al. Cancer Cell, 2012). This work has led to the fundamental discovery that ribosomal gene transcription by Pol I is not simply a “housekeeping” process in cancer cells but is highly regulated to maintain their viability (Bywater et al. Nature Reviews Cancer, 2013). Strikingly, inhibition of Pol I transcription...[Show more]
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