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Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Yan, Shunfei; Chan, Keefe; Simpson, Kaylene J.; Sanji, Elaine; Sheppard, Karen E.; Hannan, Kate; Hannan, Ross; Pearson, Richard B


Cancer is characterized by deregulated cell growth and proliferation, both of which are associated with hyperactivation of ribosome biogenesis. Inhibition of ribosome biogenesis using CX-5461, a specific inhibitor of RNA polymerase I-dependent transcription, has shown therapeutic efficacy in a MYC driven B-cell lymphoma mouse model, which is enhanced when used in combination with the mTORC1 inhibitor Everolimus. However, the therapeutic potential of CX-5461 in solid cancers is yet to be...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Molecular Cancer Research
DOI: 10.1158/1557-3125.DNAREPAIR16-A24


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