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A validated UHPLC-MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples

Parker, Suzanne L.; Guerra Valero, Yarmarly C.; Lipman, Jeffrey; Weiss, Steven; Smith, Camilla; Ruaaell, Lyndal; Smith, Paul; Roberts, Jason A; Wallis, Steven C.


Through blocking the cardiac persistent sodium current, riluzole has the potential to prevent myocardial damage post cardiac bypass surgery. A sensitive UHPLC–MS/MS method was developed and validated for quantitation of riluzole and 5-methoxypsoralen in human plasma and myocardial tissue homogenate using a liquid–liquid extraction with dichloromethane. The chromatographic separation was achieved using Shimadzu Shim-pack XR-ODS III, 2.0 × 50 mm, 1.6 μm column with a gradient mobile phase...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Biomedical Chromatography
DOI: 10.1002/bmc.4030


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