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A Total Synthesis of the Marine Alkaloid Discoipyrrole D

Zhang, Yiwen; Banwell, Martin

Description

A total synthesis of the diastereoisomeric pair of compounds, 4, assigned to the marine alkaloid discoipyrrole D is reported. A series of palladium-catalyzed cross-coupling and other reactions was employed to assemble the relevant 1,2,3,4-tetrasubstituted pyrrole (16) that was engaged in MoOPH-mediated oxidative cyclization, then conjugate addition, and redox processes to complete the synthesis. This work serves to confirm the structure (4) originally assigned to discoipyrrole D.

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/231418
Source: Journal of Organic Chemistry
DOI: 10.1021/acs.joc.7b01192
Access Rights: Open Access

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