A Total Synthesis of the Marine Alkaloid Discoipyrrole D
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Description
A total synthesis of the diastereoisomeric pair of compounds, 4, assigned to the marine alkaloid discoipyrrole D is reported. A series of palladium-catalyzed cross-coupling and other reactions was employed to assemble the relevant 1,2,3,4-tetrasubstituted pyrrole (16) that was engaged in MoOPH-mediated oxidative cyclization, then conjugate addition, and redox processes to complete the synthesis. This work serves to confirm the structure (4) originally assigned to discoipyrrole D.
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/231418 |
Source: | Journal of Organic Chemistry |
DOI: | 10.1021/acs.joc.7b01192 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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A Total Synthesis of Discoipyrrole D Final.pdf | 432.23 kB | Adobe PDF | ![]() |
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