A Total Synthesis of the Marine Alkaloid Discoipyrrole D
A total synthesis of the diastereoisomeric pair of compounds, 4, assigned to the marine alkaloid discoipyrrole D is reported. A series of palladium-catalyzed cross-coupling and other reactions was employed to assemble the relevant 1,2,3,4-tetrasubstituted pyrrole (16) that was engaged in MoOPH-mediated oxidative cyclization, then conjugate addition, and redox processes to complete the synthesis. This work serves to confirm the structure (4) originally assigned to discoipyrrole D.
|Collections||ANU Research Publications|
|Source:||Journal of Organic Chemistry|
|Access Rights:||Open Access|
|A Total Synthesis of Discoipyrrole D Final.pdf||432.23 kB||Adobe PDF|
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