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A forward genetic screen identifies a negative regulator of rapid Ca²⁺ -dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii

McCoy, James M; Stewart, Rebecca J; Uboldi, Alessandro D; Li, Dongdi; Schröder, Jan; Scott, Nicollas E; Papenfuss, Anthony T; Lehane, Adele; Foster, Leonard; Tonkin, Christopher J


Toxoplasma gondii, like all apicomplexan parasites, uses Ca2+ signaling pathways to activate gliding motility to power tissue dissemination and host cell invasion and egress. A group of “plant-like” Ca2+-dependent protein kinases (CDPKs) transduces cytosolic Ca2+ flux into enzymatic activity, but how they function is poorly understood. To investigate how Ca2+ signaling activates egress through CDPKs, we performed a forward genetic screen to isolate gain-of-function mutants from an...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M117.775114
Access Rights: Open Access


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