2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae)
-
Altmetric Citations
Auranwiwat, Chiramet; Wongsomboon, Puttandon; Thaima, Thanaphat; Rattanajak, Roonglawan; Kamchonwongpaisan, Sumalee; Willis, Anthony; Lie, Wilford; Pyne, Stephen G; Ritthiwigrom, Thunwadee
Description
Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A–C (1–3), and a new polyoxygenated cyclohexene derivative, (−)-uvaribonol F (4) together with six known compounds, 5–10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity...[Show more]
dc.contributor.author | Auranwiwat, Chiramet | |
---|---|---|
dc.contributor.author | Wongsomboon, Puttandon | |
dc.contributor.author | Thaima, Thanaphat | |
dc.contributor.author | Rattanajak, Roonglawan | |
dc.contributor.author | Kamchonwongpaisan, Sumalee | |
dc.contributor.author | Willis, Anthony | |
dc.contributor.author | Lie, Wilford | |
dc.contributor.author | Pyne, Stephen G | |
dc.contributor.author | Ritthiwigrom, Thunwadee | |
dc.date.accessioned | 2021-04-23T01:08:12Z | |
dc.identifier.issn | 0367-326X | |
dc.identifier.uri | http://hdl.handle.net/1885/230987 | |
dc.description.abstract | Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A–C (1–3), and a new polyoxygenated cyclohexene derivative, (−)-uvaribonol F (4) together with six known compounds, 5–10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falciparum stains TM4/8.2 and K1CB1 with IC50 values of 18.8 ± 3.63 and 23.4 ± 4.08 μM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC50 value of 22.1 ± 0.42 μM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC50 value of 5.05 ± 0.86 μM and was nearly equally cytotoxic to the Vero cell line | |
dc.description.sponsorship | This work was supported by a CMU Short Term Research Fellowships in Overseas. CA and PW acknowledged the Science Achievement Scholarship of Thailand (SAST), the Graduate School and The Association of Students supported by the Development and Promotion for Science and Technology talents project (ASDPST). We would like also to thank the bioassay laboratory, BIOTEC, NSTDA, Thailand for KB and Vero cells and NSTDA's Cluster Program Management for financial support to SK | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Elsevier | |
dc.rights | © 2017 Published by Elsevier B.V | |
dc.source | Fitoterapia | |
dc.subject | Uvaria cherrevensis | |
dc.subject | Annonaceae | |
dc.subject | Phenylnaphthalene | |
dc.subject | Polyoxygenated cyclohexene | |
dc.subject | Antiplasmodial activity | |
dc.subject | Cytotoxic activity | |
dc.title | 2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae) | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 120 | |
dc.date.issued | 2017 | |
local.identifier.absfor | 060101 - Analytical Biochemistry | |
local.identifier.ariespublication | a383154xPUB6168 | |
local.publisher.url | https://www.elsevier.com/en-au | |
local.type.status | Published Version | |
local.contributor.affiliation | Auranwiwat, Chiramet, Chiang Mai University | |
local.contributor.affiliation | Wongsomboon, Puttandon, Chiang Mai University | |
local.contributor.affiliation | Thaima, Thanaphat, University of Wollongong | |
local.contributor.affiliation | Rattanajak, Roonglawan, National Center for Genetic Engineering and Biotechnology | |
local.contributor.affiliation | Kamchonwongpaisan, Sumalee, National Center for Genetic Engineering and Biotechnology | |
local.contributor.affiliation | Willis, Anthony, College of Science, ANU | |
local.contributor.affiliation | Lie, Wilford, University of Wollongong | |
local.contributor.affiliation | Pyne, Stephen G, University of Wollongong | |
local.contributor.affiliation | Ritthiwigrom, Thunwadee, University of Wollongong | |
local.description.embargo | 2099-12-31 | |
local.bibliographicCitation.startpage | 103 | |
local.bibliographicCitation.lastpage | 107 | |
local.identifier.doi | 10.1016/j.fitote.2017.06.002 | |
dc.date.updated | 2020-11-23T10:04:06Z | |
local.identifier.scopusID | 2-s2.0-85020308911 | |
local.identifier.thomsonID | 000407404000015 | |
Collections | ANU Research Publications |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Auranwiwat_2-Phenylnaphthalenes_and_a_2017.pdf | 383.44 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator