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Sun exposure may protect against non-Hodgkin lymphoma: a case-control study

Hughes, Ann Maree; Armstrong, Bruce K; Vajdic, Claire M; Turner, Jennifer; Grulich, Andrew E; Fritschi, Lin; Milliken, Sam; Kaldor, John M; Benke, Geza; Kricker, Anne

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Ultraviolet radiation is a hypothesised risk factor for non-Hodgkin lymphoma (NHL) but no epidemiological study has examined this association using direct measures of sun exposure in individuals. Adults aged 20-74 years living in NSW and ACT, Australia, were the study population. Cases (704 of 829 invited to take part, 85%) were diagnosed January 2000 to August 2001. Controls (694 of 1, 136 invited to take part, 61%) were randomly selected from state electoral rolls and frequency-matched to...[Show more]

dc.contributor.authorHughes, Ann Maree
dc.contributor.authorArmstrong, Bruce K
dc.contributor.authorVajdic, Claire M
dc.contributor.authorTurner, Jennifer
dc.contributor.authorGrulich, Andrew E
dc.contributor.authorFritschi, Lin
dc.contributor.authorMilliken, Sam
dc.contributor.authorKaldor, John M
dc.contributor.authorBenke, Geza
dc.contributor.authorKricker, Anne
dc.date.accessioned2015-12-07T22:33:04Z
dc.identifier.issn0020-7136
dc.identifier.urihttp://hdl.handle.net/1885/23094
dc.description.abstractUltraviolet radiation is a hypothesised risk factor for non-Hodgkin lymphoma (NHL) but no epidemiological study has examined this association using direct measures of sun exposure in individuals. Adults aged 20-74 years living in NSW and ACT, Australia, were the study population. Cases (704 of 829 invited to take part, 85%) were diagnosed January 2000 to August 2001. Controls (694 of 1, 136 invited to take part, 61%) were randomly selected from state electoral rolls and frequency-matched to cases by age, sex and state of residence. A self-administered questionnaire and telephone interview measured outdoor hours on working and nonworking days and vacations at 10, 20, 30, 40, 50 and 60 years of age. Logistic regression models of NHL and sun exposure contained the 3 matching variables, ethnicity and sun sensitivity measures as covariates. Contrary to expectations, risk of NHL fell with increasing reported sun exposure hours. Relative to 1.0 for the lowest quarter of total sun exposure hours, the odds ratios (ORs) for successively higher quarters were 0.72 (95% CI 0.53-0.98), 0.66 (0.48-0.91) and 0.65 (0.46-0.91) (ptrend = 0.01). The association of sun exposure on nonworking days with NHL was stronger; OR for highest quarter 0.47 (0.34-0.66) (ptrend = 0.0001). Risk also fell with sun exposure on vacations; OR for highest quarter 0.60 (0.43-0.85) (ptrend = 0.003). These associations appeared strongest in women and in childhood. There was little evident trend in risk with exposure on working day. Our results provide strong statistical evidence for an inverse association between sun exposure and NHL. Increasing evidence that vitamin D may protect against cancer makes UV-mediated synthesis of vitamin D a plausible mechanism whereby sun exposure might protect against NHL.
dc.publisherJohn Wiley & Sons Inc
dc.sourceInternational Journal of Cancer
dc.subjectKeywords: vitamin D; adult; aged; article; cancer diagnosis; cancer risk; controlled study; correlation analysis; covariance; ethnology; female; frequency analysis; Hodgkin disease; human; intermethod comparison; interview; logistic regression analysis; major clini Aetiology; Case-control study; Non-Hodgkin lymphoma; Sun exposure; UV radiation
dc.titleSun exposure may protect against non-Hodgkin lymphoma: a case-control study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume112
dc.date.issued2004
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu3962038xPUB25
local.type.statusPublished Version
local.contributor.affiliationHughes, Ann Maree, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationArmstrong, Bruce K, University of Sydney
local.contributor.affiliationVajdic, Claire M, University of New South Wales
local.contributor.affiliationTurner, Jennifer, St Vincent's Hospital Sydney
local.contributor.affiliationGrulich, Andrew E, University of New South Wales
local.contributor.affiliationFritschi, Lin, University of Western Australia
local.contributor.affiliationMilliken, Sam, St Vincent's Hospital Sydney
local.contributor.affiliationKaldor, John M, University of New South Wales
local.contributor.affiliationBenke, Geza, Monash University
local.contributor.affiliationKricker, Anne, University of Sydney
local.description.embargo2037-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage865
local.bibliographicCitation.lastpage871
local.identifier.doi10.1002/ijc.20470
dc.date.updated2016-02-24T10:21:06Z
local.identifier.scopusID2-s2.0-7244224775
CollectionsANU Research Publications

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