Reactive Oxygen Species and Glucocorticoid-Induced Hypertension
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Ong, Sharon; Zhang, Yi; Whitworth, Judith
Description
1. There is increasing evidence for a role of oxidative stress and nitric oxide deficiency in experimental glucocorticoid-induced hypertension, as evidenced by increased biomarkers of oxidative stress; the effectiveness of antioxidants or reduced NADPH oxidase antagonists in lowering blood pressure; and secondary upregulation of endogenous antioxidant enzymes in response to oxidative stress. 2. In the vasculature, the main sources of superoxide are NADPH oxidase, xanthine oxidase, uncoupled...[Show more]
dc.contributor.author | Ong, Sharon | |
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dc.contributor.author | Zhang, Yi | |
dc.contributor.author | Whitworth, Judith | |
dc.date.accessioned | 2015-12-07T22:32:58Z | |
dc.identifier.issn | 0305-1870 | |
dc.identifier.uri | http://hdl.handle.net/1885/23052 | |
dc.description.abstract | 1. There is increasing evidence for a role of oxidative stress and nitric oxide deficiency in experimental glucocorticoid-induced hypertension, as evidenced by increased biomarkers of oxidative stress; the effectiveness of antioxidants or reduced NADPH oxidase antagonists in lowering blood pressure; and secondary upregulation of endogenous antioxidant enzymes in response to oxidative stress. 2. In the vasculature, the main sources of superoxide are NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide synthase (eNOS) and mitochondria. 3. NADPH oxidase plays a significant role in the pathogenesis of glucocorticoid-induced hypertension in the rats, but xanthine oxidase and uncoupled eNOS pathways are not important sources of reactive oxygen species in these models. The role of mitochondrial reactive oxygen species in glucocorticoid-induced hypertension remains to be clarified. | |
dc.publisher | Blackwell Science Asia | |
dc.source | Clinical and Experimental Pharmacology and Physiology | |
dc.subject | Keywords: acetylcysteine; antioxidant; biological marker; corticotropin; dexamethasone; endothelial nitric oxide synthase; enzyme inhibitor; glucocorticoid; nitric oxide; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; super Glucocorticoids; Hypertension; Nitric oxide; Oxidative stress; Reactive oxygen species | |
dc.title | Reactive Oxygen Species and Glucocorticoid-Induced Hypertension | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 35 | |
dc.date.issued | 2008 | |
local.identifier.absfor | 110201 - Cardiology (incl. Cardiovascular Diseases) | |
local.identifier.ariespublication | u9505948xPUB24 | |
local.type.status | Published Version | |
local.contributor.affiliation | Ong, Sharon, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Zhang, Yi, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Whitworth, Judith, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 477 | |
local.bibliographicCitation.lastpage | 482 | |
local.identifier.doi | 10.1111/j.1440-1681.2008.04900.x | |
dc.date.updated | 2015-12-07T10:25:58Z | |
local.identifier.scopusID | 2-s2.0-40149096846 | |
local.identifier.thomsonID | 000254296600026 | |
Collections | ANU Research Publications |
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