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Reactive Oxygen Species and Glucocorticoid-Induced Hypertension

Ong, Sharon; Zhang, Yi; Whitworth, Judith

Description

1. There is increasing evidence for a role of oxidative stress and nitric oxide deficiency in experimental glucocorticoid-induced hypertension, as evidenced by increased biomarkers of oxidative stress; the effectiveness of antioxidants or reduced NADPH oxidase antagonists in lowering blood pressure; and secondary upregulation of endogenous antioxidant enzymes in response to oxidative stress. 2. In the vasculature, the main sources of superoxide are NADPH oxidase, xanthine oxidase, uncoupled...[Show more]

dc.contributor.authorOng, Sharon
dc.contributor.authorZhang, Yi
dc.contributor.authorWhitworth, Judith
dc.date.accessioned2015-12-07T22:32:58Z
dc.identifier.issn0305-1870
dc.identifier.urihttp://hdl.handle.net/1885/23052
dc.description.abstract1. There is increasing evidence for a role of oxidative stress and nitric oxide deficiency in experimental glucocorticoid-induced hypertension, as evidenced by increased biomarkers of oxidative stress; the effectiveness of antioxidants or reduced NADPH oxidase antagonists in lowering blood pressure; and secondary upregulation of endogenous antioxidant enzymes in response to oxidative stress. 2. In the vasculature, the main sources of superoxide are NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide synthase (eNOS) and mitochondria. 3. NADPH oxidase plays a significant role in the pathogenesis of glucocorticoid-induced hypertension in the rats, but xanthine oxidase and uncoupled eNOS pathways are not important sources of reactive oxygen species in these models. The role of mitochondrial reactive oxygen species in glucocorticoid-induced hypertension remains to be clarified.
dc.publisherBlackwell Science Asia
dc.sourceClinical and Experimental Pharmacology and Physiology
dc.subjectKeywords: acetylcysteine; antioxidant; biological marker; corticotropin; dexamethasone; endothelial nitric oxide synthase; enzyme inhibitor; glucocorticoid; nitric oxide; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; super Glucocorticoids; Hypertension; Nitric oxide; Oxidative stress; Reactive oxygen species
dc.titleReactive Oxygen Species and Glucocorticoid-Induced Hypertension
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume35
dc.date.issued2008
local.identifier.absfor110201 - Cardiology (incl. Cardiovascular Diseases)
local.identifier.ariespublicationu9505948xPUB24
local.type.statusPublished Version
local.contributor.affiliationOng, Sharon, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationZhang, Yi, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWhitworth, Judith, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage477
local.bibliographicCitation.lastpage482
local.identifier.doi10.1111/j.1440-1681.2008.04900.x
dc.date.updated2015-12-07T10:25:58Z
local.identifier.scopusID2-s2.0-40149096846
local.identifier.thomsonID000254296600026
CollectionsANU Research Publications

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