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Optimal Dosing and Dynamic Distribution of Vaccines in an Influenza Pandemic

Wood, James; McCaw, James; Becker, Niels; Nolan, Terry; MacIntyre, C Raina


Limited production capacity and delays inherent in vaccine development are major hurdles to the widespread use of vaccines to mitigate the effects of a new influenza pandemic. Antigen-sparing vaccines have the most potential to increase population coverage but may be less efficacious. The authors explored this trade-off by applying simple models of influenza transmission and dose response to recent clinical trial data. In this paper, these data are used to illustrate an approach to comparing...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwp072


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