Optimal Dosing and Dynamic Distribution of Vaccines in an Influenza Pandemic
Limited production capacity and delays inherent in vaccine development are major hurdles to the widespread use of vaccines to mitigate the effects of a new influenza pandemic. Antigen-sparing vaccines have the most potential to increase population coverage but may be less efficacious. The authors explored this trade-off by applying simple models of influenza transmission and dose response to recent clinical trial data. In this paper, these data are used to illustrate an approach to comparing...[Show more]
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|Source:||American Journal of Epidemiology|
|01_Wood_Optimal_Dosing_and_Dynamic_2009.pdf||376.4 kB||Adobe PDF||Request a copy|
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