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Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways

Walmsley, Bruce; Berntson Eichner, Amy; Leao, Richardson; Fyffe, Robert E W

Description

Neural activity plays an important role in regulating synaptic strength and neuronal membrane properties. Attempts to establish guiding rules for activity-dependent neuronal changes have led to such concepts as homeostasis of cellular activity and Hebbian reinforcement of synaptic strength. However, it is clear that there are diverse effects resulting from activity changes, and that these changes depend on the experimental preparation, and the developmental stage of the neural circuits under...[Show more]

dc.contributor.authorWalmsley, Bruce
dc.contributor.authorBerntson Eichner, Amy
dc.contributor.authorLeao, Richardson
dc.contributor.authorFyffe, Robert E W
dc.date.accessioned2015-12-07T22:32:44Z
dc.identifier.issn0022-3751
dc.identifier.urihttp://hdl.handle.net/1885/22936
dc.description.abstractNeural activity plays an important role in regulating synaptic strength and neuronal membrane properties. Attempts to establish guiding rules for activity-dependent neuronal changes have led to such concepts as homeostasis of cellular activity and Hebbian reinforcement of synaptic strength. However, it is clear that there are diverse effects resulting from activity changes, and that these changes depend on the experimental preparation, and the developmental stage of the neural circuits under study. In addition, most experimental evidence on activity-dependent regulation comes from reduced preparations such as neuronal cultures. This review highlights recent results from studies of the intact mammalian auditory system, where changes in activity have been shown to produce alterations in synaptic and membrane properties at the level of individual neurons, and changes in network properties, including the formation of tonotopic maps.
dc.publisherCambridge University Press
dc.sourceJournal of Physiology
dc.subjectKeywords: acoustic nerve fiber; auditory nervous system; brain stem; excitatory postsynaptic potential; hearing impairment; homeostasis; hyperpolarization; nerve cell excitability; neuroanatomy; nonhuman; priority journal; review; synaptic membrane; synaptic potent
dc.titleActivity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume572
dc.date.issued2006
local.identifier.absfor110903 - Central Nervous System
local.identifier.ariespublicationu4321547xPUB24
local.type.statusPublished Version
local.contributor.affiliationWalmsley, Bruce, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBerntson Eichner, Amy, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLeao, Richardson, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFyffe, Robert E W, Wright State University
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage313
local.bibliographicCitation.lastpage321
local.identifier.doi10.1113/jphysiol.2006.104851
dc.date.updated2015-12-07T10:23:32Z
local.identifier.scopusID2-s2.0-33645523013
CollectionsANU Research Publications

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