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The natural function of the malaria parasite's chloroquine resistance transporter

Shafik, Sarah; Cobbold, Simon A.; Barkat, Kawthar; Richards, Sashika; Lancaster, Nicole; Llinas, Manuel; Hogg, Simon; Summers, Robert; McConville, Malcolm J; Martin, Rowena

Description

The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the malaria parasite, yet its natural function remains unresolved. We identify host-derived peptides of 4-11 residues, varying in both charge and composition, as the substrates of PfCRT in vitro and in situ, and show that PfCRT does not mediate the non-specific transport of other metabolites and/or ions. We find that...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/228675
Source: Nature Communications
DOI: 10.1038/s41467-020-17781-6
Access Rights: Open Access

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