Skip navigation
Skip navigation

Extracellular matrix and oxidative stress regulate human retinal pigment epithelium growth

Eamegdool, Steven; Sitiwin, Ephrem I.; Cioanca, Adrian; Madigan, Michele C

Description

Age-related macular degeneration (AMD), the most common cause of vision loss with ageing, is characterised by degeneration of the photoreceptors and retinal pigment epithelium (RPE) and changes in the extracellular matrix (ECM) underlying the RPE. The pathogenesis of AMD is still not fully understood. In this study we investigated the in vitro growth and function of primary human RPE cells in response to different ECM substrates, including nitrite-modified ECM. We initially confirmed the...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/227802
Source: Free Radical Biology and Medicine
DOI: 10.1016/j.freeradbiomed.2019.11.018

Download

File Description SizeFormat Image
01_Eamegdool_Extracellular_matrix_and_2020.pdf5.01 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator