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Extracellular matrix and oxidative stress regulate human retinal pigment epithelium growth

Eamegdool, Steven; Sitiwin, Ephrem I.; Cioanca, Adrian; Madigan, Michele C


Age-related macular degeneration (AMD), the most common cause of vision loss with ageing, is characterised by degeneration of the photoreceptors and retinal pigment epithelium (RPE) and changes in the extracellular matrix (ECM) underlying the RPE. The pathogenesis of AMD is still not fully understood. In this study we investigated the in vitro growth and function of primary human RPE cells in response to different ECM substrates, including nitrite-modified ECM. We initially confirmed the...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Free Radical Biology and Medicine
DOI: 10.1016/j.freeradbiomed.2019.11.018


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