Influenza A virus infection induces viral and cellular defective ribosomal products encoded by alternative reading frames
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Zanker, Damien; Oveissi, Sara; Tscharke, David; Duan, Mubing; Wan, Siyuan; Zhang, Xiaomu; Xiao, Kun; Mifsud, Nicole A.; Gibbs, James; Izzard, Lenny; Dlugolenski, Daniel; Faou, Pierre; Laurie, Karen; Vigneron, Nathalie; Barr, Ian G; Stambas, John; Van den Eynde, Benoit; Bennink, Jack R; Yewdell, Jonathan W; Chen, Weisan
Description
The importance of antiviral CD8+ T cell recognition of alternative reading frame (ARF)–derived peptides is uncertain. In this study, we describe an epitope (NS1-ARF21–8) present in a predicted 14-residue peptide encoded by the +1 register of NS1 mRNA in the influenza A virus (IAV). NS1-ARF21–8 elicits a robust, highly functional CD8+ T cell response in IAV-infected BALB/c mice. NS1- ARF21–8 is presented from unspliced NS mRNA, likely from downstream initiation on a Met residue that comprises...[Show more]
dc.contributor.author | Zanker, Damien | |
---|---|---|
dc.contributor.author | Oveissi, Sara | |
dc.contributor.author | Tscharke, David | |
dc.contributor.author | Duan, Mubing | |
dc.contributor.author | Wan, Siyuan | |
dc.contributor.author | Zhang, Xiaomu | |
dc.contributor.author | Xiao, Kun | |
dc.contributor.author | Mifsud, Nicole A. | |
dc.contributor.author | Gibbs, James | |
dc.contributor.author | Izzard, Lenny | |
dc.contributor.author | Dlugolenski, Daniel | |
dc.contributor.author | Faou, Pierre | |
dc.contributor.author | Laurie, Karen | |
dc.contributor.author | Vigneron, Nathalie | |
dc.contributor.author | Barr, Ian G | |
dc.contributor.author | Stambas, John | |
dc.contributor.author | Van den Eynde, Benoit | |
dc.contributor.author | Bennink, Jack R | |
dc.contributor.author | Yewdell, Jonathan W | |
dc.contributor.author | Chen, Weisan | |
dc.date.accessioned | 2021-03-24T22:45:21Z | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.uri | http://hdl.handle.net/1885/227770 | |
dc.description.abstract | The importance of antiviral CD8+ T cell recognition of alternative reading frame (ARF)–derived peptides is uncertain. In this study, we describe an epitope (NS1-ARF21–8) present in a predicted 14-residue peptide encoded by the +1 register of NS1 mRNA in the influenza A virus (IAV). NS1-ARF21–8 elicits a robust, highly functional CD8+ T cell response in IAV-infected BALB/c mice. NS1- ARF21–8 is presented from unspliced NS mRNA, likely from downstream initiation on a Met residue that comprises the P1 position of NS1-ARF21–8. Derived from a 14-residue peptide with no apparent biological function and negligible impacts on IAV infection, infectivity, and pathogenicity, NS1-ARF21–8 provides a clear demonstration of how immunosurveillance exploits natural errors in protein translation to provide antiviral immunity. We further show that IAV infection enhances a model cellular ARF translation, which potentially has important implications for virus-induced autoimmunity. | |
dc.description.sponsorship | This work was partly supported by National Health and Medical Research Council (NHMRC) Project Grants 433608 and 542508, NHMRC Senior Research Fellowship 603104 to W.C., and NHMRC Program Grant 567122. D.J.Z. was supported by an NHMRC Biomedical Postgraduate scholarship. | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | American Association of Immunologists | |
dc.rights | © 2019 by The American Association of Immunologists | |
dc.source | Journal of Immunology | |
dc.title | Influenza A virus infection induces viral and cellular defective ribosomal products encoded by alternative reading frames | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 202 | |
dc.date.issued | 2019 | |
local.identifier.absfor | 110799 - Immunology not elsewhere classified | |
local.identifier.ariespublication | u3102795xPUB3494 | |
local.publisher.url | http://www.jimmunol.org/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Zanker, Damien, La Trobe University | |
local.contributor.affiliation | Oveissi, Sara, La Trobe University | |
local.contributor.affiliation | Tscharke, David, College of Science, ANU | |
local.contributor.affiliation | Duan, Mubing, La Trobe University | |
local.contributor.affiliation | Wan, Siyuan, La Trobe University | |
local.contributor.affiliation | Zhang, Xiaomu, La Trobe University | |
local.contributor.affiliation | Xiao, Kun, La Trobe University | |
local.contributor.affiliation | Mifsud, Nicole A., La Trobe University | |
local.contributor.affiliation | Gibbs, James, National Institutes of Health | |
local.contributor.affiliation | Izzard, Lenny, Deakin University | |
local.contributor.affiliation | Dlugolenski, Daniel, Deakin University | |
local.contributor.affiliation | Faou, Pierre, La Trobe University | |
local.contributor.affiliation | Laurie, Karen, World Health Organization | |
local.contributor.affiliation | Vigneron, Nathalie, Ludwig Institute for Cancer Research | |
local.contributor.affiliation | Barr, Ian G, World Health Organisation | |
local.contributor.affiliation | Stambas, John, University of Melbourne | |
local.contributor.affiliation | Van den Eynde, Benoit, Ludwig Institute for Cancer Research | |
local.contributor.affiliation | Bennink, Jack R, National Institutes of Health | |
local.contributor.affiliation | Yewdell, Jonathan W, National Institute of Allergy & Infectious Diseases | |
local.contributor.affiliation | Chen, Weisan, LaTrobe University | |
local.description.embargo | 2099-12-31 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/433608 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/542508 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/603104 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/567122 | |
local.bibliographicCitation.issue | 12 | |
local.bibliographicCitation.startpage | 3370 | |
local.bibliographicCitation.lastpage | 3380 | |
local.identifier.doi | 10.4049/jimmunol.1900070 | |
local.identifier.absseo | 920108 - Immune System and Allergy | |
dc.date.updated | 2020-11-22T07:22:35Z | |
local.identifier.scopusID | 2-s2.0-85067219326 | |
Collections | ANU Research Publications |
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