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Influenza A virus infection induces viral and cellular defective ribosomal products encoded by alternative reading frames

Zanker, Damien; Oveissi, Sara; Tscharke, David; Duan, Mubing; Wan, Siyuan; Zhang, Xiaomu; Xiao, Kun; Mifsud, Nicole A.; Gibbs, James; Izzard, Lenny; Dlugolenski, Daniel; Faou, Pierre; Laurie, Karen; Vigneron, Nathalie; Barr, Ian G; Stambas, John; Van den Eynde, Benoit; Bennink, Jack R; Yewdell, Jonathan W; Chen, Weisan


The importance of antiviral CD8+ T cell recognition of alternative reading frame (ARF)–derived peptides is uncertain. In this study, we describe an epitope (NS1-ARF21–8) present in a predicted 14-residue peptide encoded by the +1 register of NS1 mRNA in the influenza A virus (IAV). NS1-ARF21–8 elicits a robust, highly functional CD8+ T cell response in IAV-infected BALB/c mice. NS1- ARF21–8 is presented from unspliced NS mRNA, likely from downstream initiation on a Met residue that comprises...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1900070


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