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Mamma Mia, P-glycoprotein binds again

Callaghan, Richard; Gelissen, Ingrid; George, Anthony M.; Hartz, Anika M. S.


The levels of amyloid peptides in the brain are regulated by a clearance pathway from neurons to the blood–brain barrier. The first step is thought to involve diffusion from the plasma membrane to the interstitium. However, amyloid peptides are hydrophobic and avidly intercalate within membranes. The ABC transporter P‐glycoprotein is implicated in the clearance of amyloid peptides across the blood–brain, but its role at neurons is undetermined. We here propose that P‐glycoprotein mediates...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: FEBS Letters
DOI: 10.1002/1873-3468.13951


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