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Multidimensional analysis of the microbial and genetic links in inflammatory bowel disease

Kiely, Christopher


Over 200 genes have been associated with IBD. Most of these are responsible for bacterial sensing and immune processing. Little is known about the dynamics of the gut microbiome over time, in the early Crohn's lesion and in mesenteric lymph nodes. Aims of the studies To detect differences in the IBD microbiome over time (longitudinal study), space (lymph node study) and in the early lesion (aphthous ulcers versus normal tissue). To use whole genome sequencing (WGS) to find a rare gene in a...[Show more]

CollectionsOpen Access Theses
Date published: 2021
Type: Thesis (PhD)
DOI: 10.25911/H9E9-SN74


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