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Form-Deprivation and Lens-Induced Myopia Are Similarly Affected by Pharmacological Manipulation of the Dopaminergic System in Chicks

Thomson, Kate; Karouta, Cindy; Ashby, Regan

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Purpose: Animal models have demonstrated a link between decreases in retinal dopamine levels and the development of form-deprivation myopia (FDM). However, the consistency of dopamine's role in the other major form of experimental myopia, that of lens-induced myopia (LIM), is less clear, raising the question as to what extent dopamine plays a role in human myopia. Therefore, to better define the role of dopamine in both forms of experimental myopia, we examined how consistent the protection...[Show more]

dc.contributor.authorThomson, Kate
dc.contributor.authorKarouta, Cindy
dc.contributor.authorAshby, Regan
dc.date.accessioned2021-03-19T00:43:26Z
dc.date.available2021-03-19T00:43:26Z
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/1885/227561
dc.description.abstractPurpose: Animal models have demonstrated a link between decreases in retinal dopamine levels and the development of form-deprivation myopia (FDM). However, the consistency of dopamine's role in the other major form of experimental myopia, that of lens-induced myopia (LIM), is less clear, raising the question as to what extent dopamine plays a role in human myopia. Therefore, to better define the role of dopamine in both forms of experimental myopia, we examined how consistent the protection afforded by dopamine and the dopamine agonist 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide (ADTN) is between FDM and LIM. Methods: Intravitreal injections of dopamine (0.002, 0.015, 0.150, 1.500 µmol) or ADTN (0.001, 0.010, 0.100, 1.000 µmol) were administered daily to chicks developing FDM or LIM. Axial length and refraction were measured following 4 days of treatment. To determine the receptor subtype by which dopamine and ADTN inhibit FDM and LIM, both compounds were coadministered with either the dopamine D2-like antagonist spiperone (0.005 µmol) or the D1-like antagonist SCH-23390 (0.005 µmol). Results: Intravitreal administration of dopamine or ADTN inhibited the development of FDM (ED50 = 0.003 µmol and ED50 = 0.011 µmol, respectively) and LIM (ED50 = 0.002 µmol and ED50 = 0.010 µmol, respectively) in a dose-dependent manner, with a similar degree of protection observed in both paradigms (P = 0.471 and P = 0.969, respectively). Coadministration with spiperone, but not SCH-23390, inhibited the protective effects of dopamine and ADTN against the development of both FDM (P = 0.214 and P = 0.138, respectively) and LIM (P = 0.116 and P = 0.100, respectively). Conclusions: pharmacological targeting of the retinal dopamine system inhibits FDM and LIM in a similar dose-dependent manner through a D2-like mechanism.
dc.description.sponsorshipPartially funded by ANU Connect Ventures through a Discovery Translation Fund grant (Project ID: DTF311).
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherAssociation for Research in Vision and Opthalmology
dc.rightsCopyright 2020 The Authors
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInvestigative Ophthalmology and Visual Science
dc.source.urihttps://iovs.arvojournals.org/article.aspx?articleid=2770875
dc.titleForm-Deprivation and Lens-Induced Myopia Are Similarly Affected by Pharmacological Manipulation of the Dopaminergic System in Chicks
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume61
dc.date.issued2020
local.identifier.absfor111303 - Vision Science
local.identifier.absfor111502 - Clinical Pharmacology and Therapeutics
local.identifier.ariespublicationa383154xPUB13900
local.publisher.urlhttps://iovs.arvojournals.org
local.type.statusPublished Version
local.contributor.affiliationThomson, Kate, University of Canberra
local.contributor.affiliationKarouta, Cindy, University of Canberra
local.contributor.affiliationAshby, Regan, College of Science, ANU
local.bibliographicCitation.issue12
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage13
local.identifier.doi10.1167/iovs.61.12.4
local.identifier.absseo920502 - Health Related to Ageing
local.identifier.absseo920107 - Hearing, Vision, Speech and Their Disorders
dc.date.updated2020-11-22T07:18:56Z
local.identifier.scopusID2-s2.0-85092679097
dcterms.accessRightsOpen Access
dc.provenanceThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
dc.rights.licenseCreative Commons Attribution License (CC BY)
CollectionsANU Research Publications

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