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Construction of a multivalent vaccine strain of Shigella flexneri and evaluation of serotype-specific immunity

Jennison, Amy; Roberts, Fleur; Verma, Naresh


Shigella flexneri causes more fatalities by shigellosis than any other Shigella species. There are 13 different serotypes of S. flexneri and their distribution varies between endemic geographical regions. The immune response against S. flexneri is serotype-specific, so current immunization strategies have required the administration of multiple vaccine strains to provide protection against multiple serotypes. In this study, we report the construction of a multivalent S. flexneri vaccine strain,...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: FEMS Immunology and Medical Microbiology
DOI: 10.1111/j.1574-695X.2006.00062.x


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