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Effects of Hypoxia/Reperfusion Injury on Drug Disposition in the Rat Isolated Perfused Liver

Arab, H A; Cheung, K; Hickman, Peter; Potter, Julia; Kadkhodaee, M; Roberts, M


1. Ischaemia-reperfusion injury is known to be associated with a range of functional and structural alterations in the liver. However, the effect of this injury on drug disposition is not well understood. The present study was designed to examine the effects of hypoxia/reperfusion on the disposition of glutamate and propranolol in the rat isolated perfused liver. Both glutamate and propranolol are mainly metabolised in the pericentral region of the liver. 2. Hypoxia/reperfusion was established...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.1440-1681.2007.04550.x


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