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Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example

Xie, Yiyue; Dahlin, Jayme L.; Oakley, Aaron; Casarotto, Marco; Board, Philip; Baell, Jonathan B.


Early stage drug discovery reporting on relatively new or difficult targets is often associated with insufficient hit triage. Literature reviews of such targets seldom delve into the detail required to critically analyze the associated screening hits reported. Here we take the enzyme glutathione transferase omega-1 (GSTO1-1) as an example of a relatively difficult target and review the associated literature involving small-molecule inhibitors. As part of this process we deliberately pay...[Show more]

CollectionsANU Research Publications
Date published: 2018-04-13
Type: Journal article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00318


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