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Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions

Shirokikh, Nikolay; Preiss, Thomas


Gene expression universally relies on protein synthesis, where ribosomes recognize and decode the messenger RNA template by cycling through translation initiation, elongation, and termination phases. All aspects of translation have been studied for decades using the tools of biochemistry and molecular biology available at the time. Here, we focus on the mechanism of translation initiation in eukaryotes, which is remarkably more complex than prokaryotic initiation and is the target of multiple...[Show more]

CollectionsANU Research Publications
Date published: 2018-04-06
Type: Journal article
Source: Wiley Interdisciplinary Reviews: RNA
DOI: 10.1002/wrna.1473
Access Rights: Open Access


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