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Pre- and Postsynaptic Activation of GABA-B Receptors Modulates Principal Cell Excitation in the Piriform Cortex

Gerrard, Leah; Tantirigama, Malinda; Bekkers, John


The piriform cortex (PC), like other cortical regions, normally operates in a state of dynamic equilibrium between excitation and inhibition. Here we examined the roles played by pre- and postsynaptic GABAB receptors in maintaining this equilibrium in the PC. Using whole-cell recordings in brain slices from the anterior PC of mice, we found that synaptic activation of postsynaptic GABAB receptors hyperpolarized the two major classes of layer 2 principal neurons and reduced the intrinsic...[Show more]

CollectionsANU Research Publications
Date published: 2018-02-05
Type: Journal article
Source: Frontiers in Cellular Neuroscience
DOI: 10.3389/fncel.2018.00028
Access Rights: Open Access


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