The transcription factor MYB29 is a regulator of alternative oxidase1a
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Zhang, Xinhua; Ivanova, Aneta; Vandepoele, Klaas; Radomiljac, Jordan; Van de Velde, Jan; Berkowitz, Oliver; Willems, Patrick; Xu, Yue; Ng, Sophia; Van Aken, Olivier; Duncan, Owen; Chan, Kai Xun; Pogson, Barry
Description
Plants sense and integrate a variety of signals from the environment through different interacting signal transduction pathways that involve hormones and signaling molecules. Using ALTERNATIVE OXIDASE1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, MYB DOMAIN PROTEIN29 (MYB29) was identified as a negative regulator (regulator of alternative oxidase1a 7 [rao7] mutant) in a genetic screen of Arabidopsis (Arabidopsis thaliana)....[Show more]
dc.contributor.author | Zhang, Xinhua | |
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dc.contributor.author | Ivanova, Aneta | |
dc.contributor.author | Vandepoele, Klaas | |
dc.contributor.author | Radomiljac, Jordan | |
dc.contributor.author | Van de Velde, Jan | |
dc.contributor.author | Berkowitz, Oliver | |
dc.contributor.author | Willems, Patrick | |
dc.contributor.author | Xu, Yue | |
dc.contributor.author | Ng, Sophia | |
dc.contributor.author | Van Aken, Olivier | |
dc.contributor.author | Duncan, Owen | |
dc.contributor.author | Chan, Kai Xun | |
dc.contributor.author | Pogson, Barry | |
dc.date.accessioned | 2021-03-15T22:41:49Z | |
dc.identifier.issn | 0032-0889 | |
dc.identifier.uri | http://hdl.handle.net/1885/227170 | |
dc.description.abstract | Plants sense and integrate a variety of signals from the environment through different interacting signal transduction pathways that involve hormones and signaling molecules. Using ALTERNATIVE OXIDASE1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, MYB DOMAIN PROTEIN29 (MYB29) was identified as a negative regulator (regulator of alternative oxidase1a 7 [rao7] mutant) in a genetic screen of Arabidopsis (Arabidopsis thaliana). rao7/ myb29 mutants have increased levels of AOX1a transcript and protein compared to wild type after induction with antimycin A. A variety of genes previously associated with the mitochondrial stress response also display enhanced transcript abundance, indicating that RAO7/MYB29 negatively regulates mitochondrial stress responses in general. Meta-analysis of hormoneresponsive marker genes and identification of downstream transcription factor networks revealed that MYB29 functions in the complex interplay of ethylene, jasmonic acid, salicylic acid, and reactive oxygen species signaling by regulating the expression of various ETHYLENE RESPONSE FACTOR and WRKY transcription factors. Despite an enhanced induction of mitochondrial stress response genes, rao7/myb29 mutants displayed an increased sensitivity to combined moderate light and drought stress. These results uncover interactions between mitochondrial retrograde signaling and the regulation of glucosinolate biosynthesis, both regulated by RAO7/MYB29. This common regulator can explain why perturbation of the mitochondrial function leads to transcriptomic responses overlapping with responses to biotic stress. | |
dc.description.sponsorship | This work was supported by the Australian Research Council Centre of Excellence Program (grant no. CE140100008), the Interuniversity Attraction Poles Program (grant no. IUAP P7/29) initiated by the Belgian Science Policy Office, the Ghent University Multidisciplinary Research Partnership Biotechnology for a Sustainable Economy (grant no. 01MRB510W), the Agency for Innovation by Science and Technology (IWT) in Flanders (predoctoral fellowship to J.V.d.V and D.V.), the Australian Research Council APD (fellowship and grant no. DP110102868 to O.V.A.), the Ghent University Special Research Fund (grant no. 01J11311 to P.W.), and the Research Foundation-Flanders (postdoctoral fellowship no. 12N2415N and travel grant no. V450215N to I.D.C.). | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | American Society of Plant Biologists | |
dc.rights | © 2017 American Society of Plant Biologists | |
dc.source | Plant Physiology | |
dc.title | The transcription factor MYB29 is a regulator of alternative oxidase1a | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 173 | |
dcterms.dateAccepted | 2017-01-30 | |
dc.date.issued | 2017-02-06 | |
local.identifier.absfor | 060702 - Plant Cell and Molecular Biology | |
local.identifier.ariespublication | a383154xPUB5355 | |
local.publisher.url | https://academic.oup.com/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Zhang, Xinhua, Chinese Academy of Sciences | |
local.contributor.affiliation | Ivanova, Aneta, University of Western Australia | |
local.contributor.affiliation | Vandepoele, Klaas, Center for Plant Systems Biology, | |
local.contributor.affiliation | Radomiljac, Jordan, La Trobe University | |
local.contributor.affiliation | Van de Velde, Jan, Center for Plant Systems Biology | |
local.contributor.affiliation | Berkowitz, Oliver, La Trobe University | |
local.contributor.affiliation | Willems, Patrick, Ghent University | |
local.contributor.affiliation | Xu, Yue, La Trobe University | |
local.contributor.affiliation | Ng, Sophia, University of Western Australia | |
local.contributor.affiliation | Van Aken, Olivier, University of Western Australia | |
local.contributor.affiliation | Duncan, Owen, University of Western Australia | |
local.contributor.affiliation | Chan, Kai Xun, College of Science, ANU | |
local.contributor.affiliation | Pogson, Barry, College of Science, ANU | |
local.description.embargo | 2099-12-31 | |
dc.relation | http://purl.org/au-research/grants/arc/CE140100008 | |
dc.relation | http://purl.org/au-research/grants/arc/DP110102868 | |
local.bibliographicCitation.issue | 3 | |
local.bibliographicCitation.startpage | 1824 | |
local.bibliographicCitation.lastpage | 1843 | |
local.identifier.doi | 10.1104/pp.16.01494 | |
local.identifier.absseo | 970106 - Expanding Knowledge in the Biological Sciences | |
dc.date.updated | 2020-11-23T11:21:08Z | |
local.identifier.scopusID | 2-s2.0-85014704748 | |
local.identifier.thomsonID | 000400366900024 | |
dcterms.accessRights | Open Access via publisher site | |
Collections | ANU Research Publications |
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