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Pharmacokinetics of Digoxin Cross-Reacting Substances in Patients With Acute Yellow Oleander (Thevetia peruviana) Poisoning, Including the Effect of Activated Charcoal

Roberts, Darren; Southcott, E; Potter, Julia; Roberts, M S; Eddleston, Michael; Buckley, Nicholas


Intentional self-poisonings with seeds from the yellow oleander tree (Thevetia peruviana) are widely reported. Activated charcoal has been suggested to benefit patients with yellow oleander poisoning by reducing absorption and/or facilitating elimination. Two recent randomized controlled trials (RCTs) assessing the efficacy of activated charcoal yielded conflicting outcomes in terms of mortality. The effect of activated charcoal on the pharmacokinetics of Thevetia cardenolides has not been...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Therapeutic Drug Monitoring
DOI: 10.1097/FTD.0b013e31802bfd69


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