Reappraising prazosin for night-time symptoms in post-traumatic stress disorder [LETTERS]
Post-traumatic stress disorder (PTSD) has a lifetime prevalence of approximately 10% and is associated with significant levels of psychological distress, impaired functioning and comorbidity (Kessler et al., 2005). Sleep disturbances are particularly common in PTSD and may have marked negative clinical consequences. Prazosin, a centrally acting sympatholytic alpha1-adrenergic receptor antagonist, may normalize heightened adrenergic neurotransmission in patients with PTSD. Khachatryan et al....[Show more]
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|Source:||Australian and New Zealand Journal of Psychiatry|
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