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Use of the WHO lymphoma classification in a population-based epidemiological study

Turner, Jennifer; Hughes, Ann Maree; Kricker, Anne; Milliken, Sam; Grulich, Andrew E; Kaldor, John M; Armstrong, Bruce K

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Background: Non-Hodgkin's lymphoma (NHL) is pathologically diverse. Epidemiological investigations into its increasing incidence and aetiology require accurate subtype classification. Patients and methods: Available pathology reports of 717 cases aged from 20 to 74 years in an Australian, population-based epidemiological study of NHL were reviewed by one anatomical pathologist to assign a World Health Organization (WHO) classification category. High or low confidence was assigned to the...[Show more]

dc.contributor.authorTurner, Jennifer
dc.contributor.authorHughes, Ann Maree
dc.contributor.authorKricker, Anne
dc.contributor.authorMilliken, Sam
dc.contributor.authorGrulich, Andrew E
dc.contributor.authorKaldor, John M
dc.contributor.authorArmstrong, Bruce K
dc.date.accessioned2015-12-07T22:30:24Z
dc.identifier.issn0923-7534
dc.identifier.urihttp://hdl.handle.net/1885/22301
dc.description.abstractBackground: Non-Hodgkin's lymphoma (NHL) is pathologically diverse. Epidemiological investigations into its increasing incidence and aetiology require accurate subtype classification. Patients and methods: Available pathology reports of 717 cases aged from 20 to 74 years in an Australian, population-based epidemiological study of NHL were reviewed by one anatomical pathologist to assign a World Health Organization (WHO) classification category. High or low confidence was assigned to the diagnosis of NHL, cell phenotype and WHO category and reasons given for low confidence. Results: The most informative biopsy reports were from open tissue biopsy (79% of cases), tissue core biopsy (8%), cytology (4%) and bone marrow (9%); 8% of cases had inadequate biopsies for diagnostic purposes. Immunohistochemistry or flow cytometry reports were available for 96% of cases, gene rearrangement studies for 6% and cytogenetics for 3%. The reviewer assigned high confidence to the diagnosis of NHL in 93% of cases and also the phenotype in 88%. While a WHO classification could be assigned in 91% of cases, confidence was high in only 57.5%; insufficient immunophenotyping as the commonest reason for low confidence. Conclusions: Expert pathology review of a population-based sample of NHL can provide a WHO classification category for most cases. A high level of confidence in the classification, however, would require review of diagnostic material and additional phenotyping.
dc.publisherOxford University Press
dc.sourceAnnals of Oncology
dc.subjectKeywords: acute lymphocytic leukemia; adult; aged; Australia; B cell lymphoma; bone marrow examination; cancer classification; cancer incidence; controlled study; cytogenetics; cytology; flow cytometry; genetic analysis; histopathology; Hodgkin disease; human; huma Epidemiology; NHL subtypes; Pathology report review; WHO NHL classification
dc.titleUse of the WHO lymphoma classification in a population-based epidemiological study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume15
dc.date.issued2004
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu3962038xPUB21
local.type.statusPublished Version
local.contributor.affiliationTurner, Jennifer, St Vincent's Hospital Sydney
local.contributor.affiliationHughes, Ann Maree, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKricker, Anne, University of Sydney
local.contributor.affiliationMilliken, Sam, St Vincent's Hospital Sydney
local.contributor.affiliationGrulich, Andrew E, University of New South Wales
local.contributor.affiliationKaldor, John M, University of New South Wales
local.contributor.affiliationArmstrong, Bruce K, University of Sydney
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage631
local.bibliographicCitation.lastpage637
local.identifier.doi10.1093/annonc/mdh140
dc.date.updated2015-12-07T10:04:11Z
local.identifier.scopusID2-s2.0-2342432009
CollectionsANU Research Publications

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