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An apicoplast-resident folate transporter is essential for sporogony of malaria parasites

Korbmacher, Francois; Drepper, Benjamin; Sanderson, Theo; Martin, Peer; Stach, Thomas; Maier, Alexander; Matuschewski, Kai; Matz, Joachim M.

Description

Malaria parasites are fast replicating unicellular organisms and require substantial amounts of folate for DNA synthesis. Despite the central role of this critical co-factor for parasite survival, only little is known about intraparasitic folate trafficking in Plasmodium. Here, we report on the expression, subcellular localisation and function of the parasite's folate transporter 2 (FT2) during life cycle progression in the murine malaria parasite Plasmodium berghei. Using live fluorescence...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/222888
Source: Cellular Microbiology
DOI: .1111/cmi.13266
Access Rights: Open Access

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