Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How
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Amino acids are indispensable for the growth of cancer cells. This includes essential amino acids, the carbon skeleton of which cannot be synthesized, and conditionally essential amino acids, for which the metabolic demands exceed the capacity to synthesize them. Moreover, amino acids are important signaling molecules regulating metabolic pathways, protein translation, autophagy, defense against reactive oxygen species, and many other functions. Blocking uptake of amino acids into cancer cells...[Show more]
dc.contributor.author | Broer, Stefan | |
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dc.date.accessioned | 2021-02-15T05:45:17Z | |
dc.date.available | 2021-02-15T05:45:17Z | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/1885/222887 | |
dc.description.abstract | Amino acids are indispensable for the growth of cancer cells. This includes essential amino acids, the carbon skeleton of which cannot be synthesized, and conditionally essential amino acids, for which the metabolic demands exceed the capacity to synthesize them. Moreover, amino acids are important signaling molecules regulating metabolic pathways, protein translation, autophagy, defense against reactive oxygen species, and many other functions. Blocking uptake of amino acids into cancer cells is therefore a viable strategy to reduce growth. A number of studies have used genome-wide silencing or knock-out approaches, which cover all known amino acid transporters in a large variety of cancer cell lines. In this review, these studies are interrogated together with other databases to identify vulnerabilities with regard to amino acid transport. Several themes emerge, such as synthetic lethality, reduced redundancy, and selective vulnerability, which can be exploited to stop cancer cell growth. | |
dc.description.sponsorship | This research was funded by the Australian Research Council, Grant DP180101702 and by sponsored research agreements with Merck KGaA | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | MDPI Publishing | |
dc.rights | © 2020 by the author. Licensee MDPI, Basel, Switzerland. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | International Journal of Molecular Sciences | |
dc.subject | LAT1 | |
dc.subject | ASCT2 | |
dc.subject | xCT | |
dc.subject | SNAT1 | |
dc.subject | SNAT2 | |
dc.subject | mTOR | |
dc.subject | GCN2 | |
dc.subject | solute carrier | |
dc.title | Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 21 | |
dc.date.issued | 2020 | |
local.identifier.absfor | 060110 - Receptors and Membrane Biology | |
local.identifier.ariespublication | u4008405xPUB169 | |
local.publisher.url | http://www.mdpi.com/journal/ijms | |
local.type.status | Published Version | |
local.contributor.affiliation | Broer, Stefan, College of Science, ANU | |
dc.relation | http://purl.org/au-research/grants/arc/DP180101702 | |
local.bibliographicCitation.issue | 17 | |
local.bibliographicCitation.startpage | 1 | |
local.bibliographicCitation.lastpage | 20 | |
local.identifier.doi | 10.3390/ijms21176156 | |
local.identifier.absseo | 920102 - Cancer and Related Disorders | |
dc.date.updated | 2020-11-08T07:21:14Z | |
dcterms.accessRights | Open Access | |
dc.provenance | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |
dc.rights.license | Creative Commons Attribution (CC BY) license | |
Collections | ANU Research Publications |
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