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Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How

Broer, Stefan

Description

Amino acids are indispensable for the growth of cancer cells. This includes essential amino acids, the carbon skeleton of which cannot be synthesized, and conditionally essential amino acids, for which the metabolic demands exceed the capacity to synthesize them. Moreover, amino acids are important signaling molecules regulating metabolic pathways, protein translation, autophagy, defense against reactive oxygen species, and many other functions. Blocking uptake of amino acids into cancer cells...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/222887
Source: International Journal of Molecular Sciences
DOI: 10.3390/ijms21176156
Access Rights: Open Access

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