Electronic Structure Analysis of the Dinuclear Metal Center in the Bioremediator Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes
-
Altmetric Citations
Hadler, Kieran S; Mitic, Natasa; Yip, Sylvia; Gahan, Lawrence; Ollis, David; Schenk, Gerhard; Larrabee, James A
Description
The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous, dinuclear metallohydrolase that has potential application in the remediation of organophosphate nerve agents and pesticides. GpdQ employs an unusual reaction mechanism in which the enzyme is predominantly mononuclear in the resting state, and substrate binding induces the formation of the catalytically competent dinuclear center (Hadler et al. J. Am. Chem. Soc. 2008, 130, 14129). Reactivity is further modulated by...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/22276 |
Source: | Inorganic Chemistry |
DOI: | 10.1021/ic901950c |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Hadler_Electronic_Structure_Analysis_2010.pdf | 1.42 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator