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Electronic Structure Analysis of the Dinuclear Metal Center in the Bioremediator Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes

Hadler, Kieran S; Mitic, Natasa; Yip, Sylvia; Gahan, Lawrence; Ollis, David; Schenk, Gerhard; Larrabee, James A


The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous, dinuclear metallohydrolase that has potential application in the remediation of organophosphate nerve agents and pesticides. GpdQ employs an unusual reaction mechanism in which the enzyme is predominantly mononuclear in the resting state, and substrate binding induces the formation of the catalytically competent dinuclear center (Hadler et al. J. Am. Chem. Soc. 2008, 130, 14129). Reactivity is further modulated by...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Inorganic Chemistry
DOI: 10.1021/ic901950c


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