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Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane

Carey Hulyer, Alex; Briggs, Deborah A; O'Mara, Megan; Kerr, Ian; Harmer, Jeffrey R; Callaghan, Richard


The drug efflux pump P-glycoprotein (P-gp) displays a complex transport mechanism involving multiple drug binding sites and two centres for nucleotide hydrolysis. Elucidating the molecular mechanism of transport remains elusive and the availability of P-gp structures in distinct natural and ligand trapped conformations will accelerate our understanding. The present investigation sought to provide biochemical data to validate specific features of these structures; with particular focus on the...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Journal of Structural Biology
DOI: 10.1016/j.jsb.2020.107513


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