Berman, S M; Da Paz Filho, Gilberto; Wong, Ma-Li; Kohno, Milky; Licinio, Julio; London, Edythe D.
Leptin affects eating behavior partly by altering the response of the brain to food-related stimuli. The effects of leptin on brain structure have been observed in the cerebellum, where leptin receptors are most densely expressed, but the function of leptin in the cerebellum remains unclear. We performed a nonrandomized, prospective interventional study of three adults with genetically mediated leptin deficiency. FMRI was recorded three times each year during years 5 and 6 of leptin replacement...[Show more]
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