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Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis

Vellinga, Namkje A. R.; Boerma, Christiaan; Koopmans, Matty; Donati, Abele; Dubin, Arnaldo; Shapiro, Nathan I.; Pearse, Rupert M.; van der Voort, Peter H J; Dondorp, Arjen M; Bafi, Tony; Van Haren, Frank


Background: Mildly elevated lactate levels (i.e., 1-2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, can be assessed at the bedside using sublingual direct in vivo microscopy. We aimed to evaluate the association between relative hyperlactatemia, microcirculatory flow, and outcome. Methods: This study was a predefined subanalysis of a multicenter international point prevalence...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Critical Care
DOI: 10.1186/s13054-017-1842-7
Access Rights: Open Access


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