The variable codons of H3 influenza A virus haemagglutinin genes
Gibbs, Mark; Wayper, Paul; Fourment, Mathieu; Wood, Jeffrey; Ohshima, Kazusato; Armstrong, John; Gibbs, Adrian J
We have analyzed several sets of well-studied haemagglutinin (HA) gene sequences of H3 subtype influenza A viruses to identify codons that are unusually variable, using a simple pairwise sliding window method, DnDscanning. For two of the sets there were results of detailed phylogenetic modeling studies of selection already published. A third set had been the subject of an antigen mapping study, the results of which provide a completely independent benchmark of selected changes in H3 HA genes....[Show more]
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