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Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase.

Jackson, Colin J; Foo, Jee; Tokuriki, L; Afriat, L; Carr, Paul D; Kim, Hye-Kyung; Schenk, Gerhard; Tawfik, Dan S; Ollis, David


To efficiently catalyze a chemical reaction, enzymes are required to maintain fast rates for formation of the Michaelis complex, the chemical reaction and product release. These distinct demands could be satisfied via fluctuation between different conformational substates (CSs) with unique configurations and catalytic properties. However, there is debate as to how these rapid conformational changes, or dynamics, exactly affect catalysis. As a model system, we have studied bacterial...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0907548106


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